The best way to treat an oral mucosal lesion is to diagnose it, and tissue biopsy is the gold standard for detecting disease, oral or otherwise. The moist and limited environment of the mouth makes it difficult to obtain a viable tissue sample appropriate for diagnosis. A biopsy is the surgical removal of a tissue sample from a living person to present a representative, likely specimen to the pathologist for histopathology performance and diagnosis. This method is employed for all body tissues, including those in the oral cavity, where many disease processes can occur.

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